Polyarginine induces an antitumor immune response through binding to toll-like receptor 4.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC4116740 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Polyarginine induces an antitumor immune response through binding to toll-like receptor 4.
Yang Yong Y Wolfram Joy J Fang Xiaohong X Shen Haifa H Ferrari Mauro M
Small (Weinheim an der Bergstrasse, Germany) 20131210 7
A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy. ...[more]
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