Ontology highlight
ABSTRACT:
SUBMITTER: Kode A
PROVIDER: S-EPMC4116754 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Kode Aruna A Manavalan John S JS Mosialou Ioanna I Bhagat Govind G Rathinam Chozha V CV Luo Na N Khiabanian Hossein H Lee Albert A Murty Vundavalli V VV Friedman Richard R Brum Andrea A Park David D Galili Naomi N Mukherjee Siddhartha S Teruya-Feldstein Julie J Raza Azra A Rabadan Raul R Berman Ellin E Kousteni Stavroula S
Nature 20140115 7487
Cells of the osteoblast lineage affect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic stem cell mobilization and lineage determination and B cell lymphopoiesis. Osteoblasts were recently implicated in pre-leukaemic conditions in mice. However, a single genetic change in osteoblasts that can induce leukaemogenesis has not been shown. Here we show that an activating mutation of β-catenin in mouse osteoblasts alters the differentiation potential of mye ...[more]