Ontology highlight
ABSTRACT:
SUBMITTER: Cao L
PROVIDER: S-EPMC4117229 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Cao Lin L McCaig Colin D CD Scott Roderick H RH Zhao Siwei S Milne Gillian G Clevers Hans H Zhao Min M Pu Jin J
Journal of cell science 20140613 Pt 15
The apicobasal polarity of enterocytes determines where the brush border membrane (apical membrane) will form, but how this apical membrane faces the lumen is not well understood. The electrical signal across the epithelium could serve as a coordinating cue, orienting and polarizing enterocytes. Here, we show that applying a physiological electric field to intestinal epithelial cells, to mimic the natural electric field created by the transepithelial potential difference, polarized phosphorylati ...[more]