Ontology highlight
ABSTRACT:
SUBMITTER: Valenzuela JI
PROVIDER: S-EPMC4117232 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Valenzuela José I JI Jaureguiberry-Bravo Matías M Salas Daniela A DA Ramírez Omar A OA Cornejo Víctor H VH Lu Hsiangmin E HE Blanpied Thomas A TA Couve Andrés A
Journal of cell science 20140603 Pt 15
In neurons, secretory organelles within the cell body are complemented by the dendritic endoplasmic reticulum (ER) and Golgi outposts (GOPs), whose role in neurotransmitter receptor trafficking is poorly understood. γ-aminobutyric acid (GABA) type B metabotropic receptors (GABABRs) regulate the efficacy of synaptic transmission throughout the brain. Their plasma membrane availability is controlled by mechanisms involving an ER retention motif and assembly-dependent ER export. Thus, they constitu ...[more]