Ontology highlight
ABSTRACT:
SUBMITTER: Sacher AG
PROVIDER: S-EPMC4117471 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Sacher Adrian G AG Jänne Pasi A PA Oxnard Geoffrey R GR
Cancer 20140417 15
The widespread adoption of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for the first-line treatment of patients with advanced EGFR-mutated non-small cell lung cancer has resulted in acquired tyrosine kinase inhibitor resistance becoming a ubiquitous clinical problem. The identification of specific mechanisms of acquired resistance has allowed a better understanding of the biology and natural history of resistant disease, but is only now starting to impact treatment decisio ...[more]