MiR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Ufkin ML
PROVIDER: S-EPMC4117580 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
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miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia.
Ufkin Melanie L ML Peterson Sarah S Yang Xuehui X Driscoll Heather H Duarte Christine C Sathyanarayana Pradeep P
Leukemia research 20140108 3
microRNA profiling of acute myeloid leukemia patient samples identified miR-125a as being decreased. Current literature has investigated miR-125a's role in normal hematopoiesis but not within acute myeloid leukemia. Analysis of the upstream region of miR-125a identified several CpG islands. Both precursor and mature miR-125a increased in response to a de-methylating agent, Decitabine. Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a. Either ectopic expression ...[more]
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