Optimal back-extrapolation method for estimating plasma volume in humans using the indocyanine green dilution method.

ABSTRACT:

Background

The indocyanine green dilution method is one of the methods available to estimate plasma volume, although some researchers have questioned the accuracy of this method.

Methods

We developed a new, physiologically based mathematical model of indocyanine green kinetics that more accurately represents indocyanine green kinetics during the first few minutes postinjection than what is assumed when using the traditional mono-exponential back-extrapolation method. The mathematical model is used to develop an optimal back-extrapolation method for estimating plasma volume based on simulated indocyanine green kinetics obtained from the physiological model.

Results

Results from a clinical study using the indocyanine green dilution method in 36 subjects with type 2 diab

SUBMITTER: Polidori D 

PROVIDER: S-EPMC4118208 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature