Ontology highlight
ABSTRACT:
SUBMITTER: Parra V
PROVIDER: S-EPMC4118291 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Parra Valentina V Moraga Francisco F Kuzmicic Jovan J López-Crisosto Camila C Troncoso Rodrigo R Torrealba Natalia N Criollo Alfredo A Díaz-Elizondo Jessica J Rothermel Beverly A BA Quest Andrew F G AF Lavandero Sergio S
Biochimica et biophysica acta 20130416 8
Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulate numerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In cardiomyocytes, ceramides induce apoptosis by decreasing mitochondrial membrane potential and promoting cytochrome-c release. Ca(2+) overload is a common feature of all types of cell death. The aim of this study was to determine the effect of ceramides on cytoplasmic Ca(2+) levels, mitoch ...[more]