Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4118494 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Wang Yan Y Telesford Kiel M KM Ochoa-Repáraz Javier J Haque-Begum Sakhina S Christy Marc M Kasper Eli J EJ Wang Li L Wu Yan Y Robson Simon C SC Kasper Dennis L DL Kasper Lloyd H LH
Nature communications 20140721
The mammalian immune system constitutively senses vast quantities of commensal bacteria and their products through pattern recognition receptors, yet excessive immune reactivity is prevented under homeostasis. The intestinal microbiome can influence host susceptibility to extra-intestinal autoimmune disorders. Here we report that polysaccharide A (PSA), a symbiosis factor for the human intestinal commensal Bacteroides fragilis, protects against central nervous system demyelination and inflammati ...[more]