Ontology highlight
ABSTRACT:
SUBMITTER: Shestov AA
PROVIDER: S-EPMC4118620 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Shestov Alexander A AA Liu Xiaojing X Ser Zheng Z Cluntun Ahmad A AA Hung Yin P YP Huang Lei L Kim Dongsung D Le Anne A Yellen Gary G Albeck John G JG Locasale Jason W JW
eLife 20140709
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and statistical simulations. We identified and confirmed a novel mode of regulation specific to aerobic glycolysis where flux t ...[more]