Mouse Models of 22q11.2-Associated Autism Spectrum Disorder.
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ABSTRACT:
SUBMITTER: Hiroi N
PROVIDER: S-EPMC4118685 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Mouse Models of 22q11.2-Associated Autism Spectrum Disorder.
Hiroi Noboru N Hiramoto Takeshi T Harper Kathryn M KM Suzuki Go G Boku Shuken S
Autism-open access 20120101
Copy number variation (CNV) of human chromosome 22q11.2 is associated with an elevated rate of autism spectrum disorder (ASD) and represents one of syndromic ASDs with rare genetic variants. However, the precise genetic basis of this association remains unclear due to its relatively large hemizygous and duplication region, including more than 30 genes. Previous studies using genetic mouse models suggested that although not all 22q11.2 genes contribute to ASD symptomatology, more than one 22q11.2 ...[more]
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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
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