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Democratizing systems immunology with modular transcriptional repertoire analyses.

ABSTRACT: Individual elements that constitute the immune system have been characterized over the few past decades, mostly through reductionist approaches. The introduction of large-scale profiling platforms has more recently facilitated the assessment of these elements on a global scale. However, the analysis and the interpretation of such large-scale datasets remains a challenge and a barrier for the wider adoption of systems approaches in immunological and clinical studies. In this Innovation article, we describe an analytical strategy that relies on the a priori determination of co-dependent gene sets for a given biological system. Such modular transcriptional repertoires can in turn be used to simplify the analysis and the interpretation of large-scale datasets, and to design targeted immune fingerprinting assays and web applications that will further facilitate the dissemination of systems approaches in immunology.

SUBMITTER: Chaussabel D

PROVIDER: S-EPMC4118927 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Democratizing systems immunology with modular transcriptional repertoire analyses.

Chaussabel Damien D Baldwin Nicole N

Nature reviews. Immunology 20140401 4

Individual elements that constitute the immune system have been characterized over the few past decades, mostly through reductionist approaches. The introduction of large-scale profiling platforms has more recently facilitated the assessment of these elements on a global scale. However, the analysis and the interpretation of such large-scale datasets remains a challenge and a barrier for the wider adoption of systems approaches in immunological and clinical studies. In this Innovation article, w ...[more]

PMID: 24662387

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