Ontology highlight
ABSTRACT:
SUBMITTER: Caballero D
PROVIDER: S-EPMC4119278 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Caballero David D Voituriez Raphaël R Riveline Daniel D
Biophysical journal 20140701 1
Many physiological phenomena involve directional cell migration. It is usually attributed to chemical gradients in vivo. Recently, other cues have been shown to guide cells in vitro, including stiffness/adhesion gradients or micropatterned adhesive motifs. However, the cellular mechanism leading to these biased migrations remains unknown, and, often, even the direction of motion is unpredictable. In this study, we show the key role of fluctuating protrusions on ratchet-like structures in driving ...[more]