Ontology highlight
ABSTRACT:
SUBMITTER: Park SW
PROVIDER: S-EPMC4119393 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Park Sung Wook SW Kim Jin Hyoung JH Kim Ko-Eun KE Jeong Moon Hee MH Park Hyunsung H Park Bongju B Suh Young-Ger YG Park Woo Jin WJ Kim Jeong Hun JH
Journal of cellular and molecular medicine 20140218 5
Retinal neovascularization in retinopathy of prematurity (ROP) is the most common cause of blindness for children. Despite evidence that hypoxia inducible factor (HIF)-1α -VEGF axis is associated with the pathogenesis of ROP, the inhibitors of HIF-1α have not been established as a therapeutic target in the control of ROP pathophysiology. We investigated the hypothesis that degradation of HIF-1α as a master regulator of angiogenesis in hypoxic condition, using β-lapachone, would confer protection ...[more]