Competing targets of microRNA-608 affect anxiety and hypertension.
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ABSTRACT:
SUBMITTER: Hanin G
PROVIDER: S-EPMC4119407 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Competing targets of microRNA-608 affect anxiety and hypertension.
Hanin Geula G Shenhar-Tsarfaty Shani S Yayon Nadav N Yau Yin Hoe YH Bennett Estelle R ER Sklan Ella H EH Rao Dabeeru C DC Rankinen Tuomo T Bouchard Claude C Geifman-Shochat Susana S Shifman Sagiv S Greenberg David S DS Soreq Hermona H
Human molecular genetics 20140409 17
MicroRNAs (miRNAs) can repress multiple targets, but how a single de-balanced interaction affects others remained unclear. We found that changing a single miRNA-target interaction can simultaneously affect multiple other miRNA-target interactions and modify physiological phenotype. We show that miR-608 targets acetylcholinesterase (AChE) and demonstrate weakened miR-608 interaction with the rs17228616 AChE allele having a single-nucleotide polymorphism (SNP) in the 3'-untranslated region (3'UTR) ...[more]
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