Ontology highlight
ABSTRACT:
SUBMITTER: Wilson BJ
PROVIDER: S-EPMC4119553 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Wilson Brian J BJ Saab Karim R KR Ma Jie J Schatton Tobias T Pütz Pablo P Zhan Qian Q Murphy George F GF Gasser Martin M Waaga-Gasser Ana Maria AM Frank Natasha Y NY Frank Markus H MH
Cancer research 20140616 15
The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical disease progression and tumor recurrence. ABCB5 confers therapeutic resistance, but other functions in tumorigenesis independent of drug efflux have not been described that might help explain why it is so broadly overexpressed in human cancer. Here we show that in melanoma-initiating cells, ABCB5 controls IL1β secretion, which serves to maintai ...[more]