RGS2 is a feedback inhibitor of melatonin production in the pineal gland.
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ABSTRACT:
SUBMITTER: Matsuo M
PROVIDER: S-EPMC4119756 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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RGS2 is a feedback inhibitor of melatonin production in the pineal gland.
Matsuo Masahiro M Coon Steven L SL Klein David C DC
FEBS letters 20130321 9
The 24-h rhythmic production of melatonin by the pineal gland is essential for coordinating circadian physiology. Melatonin production increases at night in response to the release of norepinephrine from sympathetic nerve processes which innervate the pineal gland. This signal is transduced through G-protein-coupled adrenergic receptors. Here, we found that the abundance of regulator of G-protein signaling 2 (RGS2) increases at night, that expression is increased by norepinephrine and that this ...[more]
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