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68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers.

ABSTRACT: We have developed a (68)Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

SUBMITTER: Nichols B

PROVIDER: S-EPMC4119763 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers.

Nichols Brandon B Qin Zhengtao Z Yang Jun J Vera David R DR Devaraj Neal K NK

Chemical communications (Cambridge, England) 20140304 40

We have developed a (68)Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo. ...[more]

PMID: 24589653

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