Ontology highlight
ABSTRACT:
SUBMITTER: Lauchle JO
PROVIDER: S-EPMC4119783 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Lauchle Jennifer O JO Kim Doris D Le Doan T DT Akagi Keiko K Crone Michael M Krisman Kimberly K Warner Kegan K Bonifas Jeannette M JM Li Qing Q Coakley Kristen M KM Diaz-Flores Ernesto E Gorman Matthew M Przybranowski Sally S Tran Mary M Kogan Scott C SC Roose Jeroen P JP Copeland Neal G NG Jenkins Nancy A NA Parada Luis L Wolff Linda L Sebolt-Leopold Judith J Shannon Kevin K
Nature 20090902 7262
The cascade comprising Raf, mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK) is a therapeutic target in human cancers with deregulated Ras signalling, which includes tumours that have inactivated the Nf1 tumour suppressor. Nf1 encodes neurofibromin, a GTPase-activating protein that terminates Ras signalling by stimulating hydrolysis of Ras-GTP. We compared the effects of inhibitors of MEK in a myeloproliferative disorder (MPD) initiated by inactivatin ...[more]