Ontology highlight
ABSTRACT:
SUBMITTER: Epler K
PROVIDER: S-EPMC4119887 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Advanced healthcare materials 20120402 3
Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes. ...[more]