Ontology highlight
ABSTRACT:
SUBMITTER: Hezel AF
PROVIDER: S-EPMC4119993 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Hezel A F AF Noel M S MS Allen J N JN Abrams T A TA Yurgelun M M Faris J E JE Goyal L L Clark J W JW Blaszkowsky L S LS Murphy J E JE Zheng H H Khorana A A AA Connolly G C GC Hyrien O O Baran A A Herr M M Ng K K Sheehan S S Harris D J DJ Regan E E Borger D R DR Iafrate A J AJ Fuchs C C Ryan D P DP Zhu A X AX
British journal of cancer 20140624 3
<h4>Background</h4>Current data suggest that platinum-based combination therapy is the standard first-line treatment for biliary tract cancer. EGFR inhibition has proven beneficial across a number of gastrointestinal malignancies; and has shown specific advantages among KRAS wild-type genetic subtypes of colon cancer. We report the combination of panitumumab with gemcitabine (GEM) and oxaliplatin (OX) as first-line therapy for KRAS wild-type biliary tract cancer.<h4>Methods</h4>Patients with his ...[more]