Ontology highlight
ABSTRACT:
SUBMITTER: Friedli M
PROVIDER: S-EPMC4120079 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Friedli Marc M Turelli Priscilla P Kapopoulou Adamandia A Rauwel Benjamin B Castro-Díaz Nathaly N Rowe Helen M HM Ecco Gabriela G Unzu Carmen C Planet Evarist E Lombardo Angelo A Mangeat Bastien B Wildhaber Barbara E BE Naldini Luigi L Trono Didier D
Genome research 20140530 8
Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens and transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, we asked how ERE control is maintained during the generation of induced pluripotent stem cells (iPSCs), as this procedure involves profound epigenetic remodeling. We found that all EREs tested were markedly up-regulated during the reprogramming of either mouse embryonic fibrob ...[more]