Human hemato-lymphoid system mice: current use and future potential for medicine.
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ABSTRACT:
SUBMITTER: Rongvaux A
PROVIDER: S-EPMC4120191 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Human hemato-lymphoid system mice: current use and future potential for medicine.
Rongvaux Anthony A Takizawa Hitoshi H Strowig Till T Willinger Tim T Eynon Elizabeth E EE Flavell Richard A RA Manz Markus G MG
Annual review of immunology 20130116
To directly study complex human hemato-lymphoid system physiology and respective system-associated diseases in vivo, human-to-mouse xenotransplantation models for human blood and blood-forming cells and organs have been developed over the past three decades. We here review the fundamental requirements and the remarkable progress made over the past few years in improving these systems, the current major achievements reached by use of these models, and the future challenges to more closely model a ...[more]
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