Ontology highlight
ABSTRACT:
SUBMITTER: Raggio CL
PROVIDER: S-EPMC4120267 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091001 10
Adolescent idiopathic scoliosis (AIS) is a common disorder with strong evidence for genetic predisposition. Quantitative trait loci (QTLs) for AIS susceptibility have been identified on chromosomes. We performed a genome-wide genetic linkage scan in seven multiplex families using 400 marker loci with a mean spacing of 8.6 cM. We used Genehunter Plus to generate linkage statistics, expressed as homogeneity (HLOD) scores, under dominant and recessive genetic models. We found a significant linkage ...[more]