Ontology highlight
ABSTRACT:
SUBMITTER: Grive KJ
PROVIDER: S-EPMC4120270 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Grive Kathryn J KJ Seymour Kimberly A KA Mehta Rajvi R Freiman Richard N RN
Developmental biology 20140513 1
Primary ovarian insufficiency (POI) affects 1% of women under the age of 40 and is associated with premature ovarian follicle depletion. TAF4b deficiency in adult female mouse models results in hallmarks of POI including stereotyped gonadotropin alterations indicative of early menopause, poor oocyte quality, and infertility. However, the precise developmental mechanisms underlying these adult deficits remain unknown. Here we show that TAF4b is required for the initial establishment of the primor ...[more]