Ontology highlight
ABSTRACT:
SUBMITTER: Davis ME
PROVIDER: S-EPMC4120867 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Davis Meredith E ME Wang May K MK Rennick Linda J LJ Full Florian F Gableske Sebastian S Mesman Annelies W AW Gringhuis Sonja I SI Geijtenbeek Teunis B H TB Duprex W Paul WP Gack Michaela U MU
Cell host & microbe 20140701 1
The cytosolic sensor MDA5 is crucial for antiviral innate immune defense against various RNA viruses including measles virus; as such, many viruses have evolved strategies to antagonize the antiviral activity of MDA5. Here, we show that measles virus escapes MDA5 detection by targeting the phosphatases PP1α and PP1γ, which regulate MDA5 activity by removing an inhibitory phosphorylation mark. The V proteins of measles virus and the related paramyxovirus Nipah virus interact with PP1α/γ, preventi ...[more]