Ontology highlight
ABSTRACT:
SUBMITTER: Rothwell PE
PROVIDER: S-EPMC4120877 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Rothwell Patrick E PE Fuccillo Marc V MV Maxeiner Stephan S Hayton Scott J SJ Gokce Ozgun O Lim Byung Kook BK Fowler Stephen C SC Malenka Robert C RC Südhof Thomas C TC
Cell 20140701 1
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the corresponding mutations produce robust synaptic and behavioral changes. However, different neuroligin-3 mutations cause largely distinct phenotypes in mice, and no causal relationship links a specific synaptic dysfunction to a behavioral change. Using rotarod motor learning as a proxy for acquired repetitive behaviors in mice, we found that different neuroligin-3 mutations uniformly enhanced formation of repetitiv ...[more]