Selenopeptide transamidation and metathesis.
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ABSTRACT:
SUBMITTER: Ollivier N
PROVIDER: S-EPMC4120982 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Selenopeptide transamidation and metathesis.
Ollivier Nathalie N Blanpain Annick A Boll Emmanuelle E Raibaut Laurent L Drobecq Hervé H Melnyk Oleg O
Organic letters 20140714 15
Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported. ...[more]
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