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Selenopeptide transamidation and metathesis.


ABSTRACT: Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.

SUBMITTER: Ollivier N 

PROVIDER: S-EPMC4120982 | biostudies-literature |

REPOSITORIES: biostudies-literature

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