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Directing neuronal signaling through cell-surface glycan engineering.


ABSTRACT: The ability to tailor plasma membranes with specific glycans may enable the control of signaling events that are critical for proper development and function. We report a method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans using chemically modified liposomes. Neurons engineered to display CS-E-enriched polysaccharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced axonal growth. This approach provides a facile, general route to tailor cell membranes with biologically active glycans and demonstrates the potential to direct important cellular events through cell-surface glycan engineering.

SUBMITTER: Pulsipher A 

PROVIDER: S-EPMC4120997 | biostudies-literature |

REPOSITORIES: biostudies-literature

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