IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in Chinese Han population.

ABSTRACT:

Background

The objective of this study was to systematically evaluate the contribution of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to type 2 diabetes mellitus (T2DM) and its interaction with obesity to T2DM susceptibility.

Methods

To clarify whether IGF2BP2 is an independent risk factor for T2DM in Chinese population, we conducted a study with a total of 2,301 Chinese Han subjects, including 1,166 T2DM patients and 1,135 controls, for the genotype of a most common and widely studied polymorphism-rs4402960 of IGF2BP2. Genotyping was performed by iPLEX technology. Gene and environment interaction analysis was performed by using multiple logistic regression models.

Results

The repeatedly confirmed association between IGF2BP2 (rs4402960) and T2DM

SUBMITTER: Wu HH 

PROVIDER: S-EPMC4121008 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature