Dataset Information

Sexual dimorphisms in the associations of BMI and body fat with indices of pubertal development in girls and boys.

ABSTRACT:

Context

The effect of obesity and concomitant insulin resistance on pubertal development is incompletely elucidated.

Objective

To determine how measures of adiposity and insulin resistance are associated with pubertal maturation in boys and girls.

Setting and design

Breast and pubic hair Tanner stage and testicular volume by orchidometry were determined by physical examination in 1066 children. Ovarian volume was estimated by trans-abdominal ultrasound. Fat mass, skeletal age, and fasting serum for insulin and glucose, total T, estradiol, estrone, dehydroepiandrosterone-sulfate, and androstenedione were measured at the National Institutes of Health Clinical Research Center. Convenience sample; 52% obese, 59% female.