Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma.
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ABSTRACT:
SUBMITTER: Zanier ER
PROVIDER: S-EPMC4121458 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma.
Zanier Elisa R ER Pischiutta Francesca F Riganti Loredana L Marchesi Federica F Turola Elena E Fumagalli Stefano S Perego Carlo C Parotto Emanuela E Vinci Paola P Veglianese Pietro P D'Amico Giovanna G Verderio Claudia C De Simoni Maria-Grazia MG
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20140701 3
Microglia/macrophages (M) are major contributors to postinjury inflammation, but they may also promote brain repair in response to specific environmental signals that drive classic (M1) or alternative (M2) polarization. We investigated the activation and functional changes of M in mice with traumatic brain injuries and receiving intracerebroventricular human bone marrow mesenchymal stromal cells (MSCs) or saline infusion. MSCs upregulated Ym1 and Arginase-1 mRNA (p < 0.001), two M2 markers of pr ...[more]
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