Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss.
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ABSTRACT:
SUBMITTER: Dymowska AK
PROVIDER: S-EPMC4121585 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss.
Dymowska Agnieszka K AK Schultz Aaron G AG Blair Salvatore D SD Chamot Danuta D Goss Greg G GG
American journal of physiology. Cell physiology 20140604 3
A role for acid-sensing ion channels (ASICs) to serve as epithelial channels for Na(+) uptake by the gill of freshwater rainbow trout was investigated. We found that the ASIC inhibitors 4',6-diamidino-2-phenylindole and diminazene decreased Na(+) uptake in adult rainbow trout in a dose-dependent manner, with IC50 values of 0.12 and 0.96 μM, respectively. Furthermore, we cloned the trout ASIC1 and ASIC4 homologs and demonstrated that they are expressed differentially in the tissues of the rainbow ...[more]
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