Ontology highlight
ABSTRACT:
SUBMITTER: Mavrakis KJ
PROVIDER: S-EPMC4121855 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Mavrakis Konstantinos J KJ Van Der Meulen Joni J Wolfe Andrew L AL Liu Xiaoping X Mets Evelien E Taghon Tom T Khan Aly A AA Setty Manu M Rondou Pieter P Vandenberghe Peter P Delabesse Eric E Benoit Yves Y Socci Nicholas B NB Leslie Christina S CS Van Vlierberghe Pieter P Speleman Frank F Wendel Hans-Guido HG
Nature genetics 20110605 7
The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed ...[more]