Ontology highlight
ABSTRACT:
SUBMITTER: Gagliardi PA
PROVIDER: S-EPMC4121984 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
The Journal of cell biology 20140801 3
Directional cell migration is of paramount importance in both physiological and pathological processes, such as development, wound healing, immune response, and cancer invasion. Here, we report that 3-phosphoinositide-dependent kinase 1 (PDK1) regulates epithelial directional migration and invasion by binding and activating myotonic dystrophy kinase-related CDC42-binding kinase α (MRCKα). We show that the effect of PDK1 on cell migration does not involve its kinase activity but instead relies on ...[more]