Ontology highlight
ABSTRACT:
SUBMITTER: Nunes T
PROVIDER: S-EPMC4121991 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nunes Tiago T Bernardazzi Claudio C de Souza Heitor S HS
BioMed research international 20140714
Cell death mechanisms have been associated with the development of inflammatory bowel diseases in humans and mice. Recent studies suggested that a complex crosstalk between autophagy/apoptosis, microbe sensing, and enhanced endoplasmic reticulum stress in the epithelium could play a critical role in these diseases. In addition, necroptosis, a relatively novel programmed necrosis-like pathway associated with TNF receptor activation, seems to be also present in the pathogenesis of Crohn's disease ...[more]