Ontology highlight
ABSTRACT:
SUBMITTER: Mizumoto S
PROVIDER: S-EPMC4122003 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mizumoto Shuji S Yamada Shuhei S Sugahara Kazuyuki K
BioMed research international 20140713
Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective monosaccharides by various glycosyltransferases and maturated by epimerases and sulfotransferases. The structural diversity of GAG polysaccharides, including their sulfation patterns and sequential arrangements, is essential for a wide range of biological activities such as cell signaling, cell proliferation, tissue morphogenesis, and interactions with various growth factors. Studies using knockout mice of enzy ...[more]