Ontology highlight
ABSTRACT:
SUBMITTER: Roix JJ
PROVIDER: S-EPMC4122340 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Roix Jeffrey J JJ Harrison S D SD Rainbolt Elizabeth A EA Meshaw Kathryn R KR McMurry Avery S AS Cheung Peter P Saha Saurabh S
PloS one 20140805 8
Approved drugs target approximately 400 different mechanisms of action, of which as few as 60 are currently used as anti-cancer therapies. Given that on average it takes 10-15 years for a new cancer therapeutic to be approved, and the recent success of drug repurposing for agents such as thalidomide, we hypothesized that effective, safe cancer treatments may be found by testing approved drugs in new therapeutic settings. Here, we report in-vivo testing of a broad compound collection in cancer xe ...[more]