Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC4122422 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Li Sandra S Pettersson Ulrika S US Hoorelbeke Bart B Kolaczkowska Elzbieta E Schelfhout Katrien K Martens Erik E Kubes Paul P Van Damme Jo J Phillipson Mia M Opdenakker Ghislain G
PloS one 20140805 8
In vivo leukocyte recruitment is not fully understood and may result from interactions of chemokines with glycosaminoglycans/GAGs. We previously showed that chlorite-oxidized oxyamylose/COAM binds the neutrophil chemokine GCP-2/CXCL6. Here, mouse chemokine binding by COAM was studied systematically and binding affinities of chemokines to COAM versus GAGs were compared. COAM and heparan sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemoki ...[more]