Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4122615 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.
Wang Jianglin J Yang Mingying M Zhu Ye Y Wang Lin L Tomsia Antoni P AP Mao Chuanbin C
Advanced materials (Deerfield Beach, Fla.) 20140407 29
A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs. ...[more]
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