Ontology highlight
ABSTRACT:
SUBMITTER: Nishida M
PROVIDER: S-EPMC4123552 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Nishida Motohiro M Sawa Tomohiro T Kitajima Naoyuki N Ono Katsuhiko K Inoue Hirofumi H Ihara Hideshi H Motohashi Hozumi H Yamamoto Masayuki M Suematsu Makoto M Kurose Hitoshi H van der Vliet Albert A Freeman Bruce A BA Shibata Takahiro T Uchida Koji K Kumagai Yoshito Y Akaike Takaaki T
Nature chemical biology 20120701 8
An emerging aspect of redox signaling is the pathway mediated by electrophilic byproducts, such as nitrated cyclic nucleotide (for example, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP)) and nitro or keto derivatives of unsaturated fatty acids, generated via reactions of inflammation-related enzymes, reactive oxygen species, nitric oxide and secondary products. Here we report that enzymatically generated hydrogen sulfide anion (HS(-)) regulates the metabolism and signaling actions o ...[more]