Ontology highlight
ABSTRACT:
SUBMITTER: Ni Z
PROVIDER: S-EPMC4124035 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ni Zuyao Z Xu Chao C Guo Xinghua X Hunter Gerald O GO Kuznetsova Olga V OV Tempel Wolfram W Marcon Edyta E Zhong Guoqing G Guo Hongbo H Kuo Wei-Hung William WW Li Joyce J Young Peter P Olsen Jonathan B JB Wan Cuihong C Loppnau Peter P El Bakkouri Majida M Senisterra Guillermo A GA He Hao H Huang Haiming H Sidhu Sachdev S SS Emili Andrew A Murphy Shona S Mosley Amber L AL Arrowsmith Cheryl H CH Min Jinrong J Greenblatt Jack F JF
Nature structural & molecular biology 20140706 8
The RNA polymerase II (RNAPII) C-terminal domain (CTD) heptapeptide repeats (1-YSPTSPS-7) undergo dynamic phosphorylation and dephosphorylation during the transcription cycle to recruit factors that regulate transcription, RNA processing and chromatin modification. We show here that RPRD1A and RPRD1B form homodimers and heterodimers through their coiled-coil domains and interact preferentially via CTD-interaction domains (CIDs) with RNAPII CTD repeats phosphorylated at S2 and S7. Crystal structu ...[more]