Ontology highlight
ABSTRACT:
SUBMITTER: Lee MN
PROVIDER: S-EPMC4124741 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140301 6175
Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells. We identified 121 common genetic variants associated in cis with variation in expression responses to Escherichia coli lipopolysaccharide, influenza, or interferon-β (IFN-β). We localized and va ...[more]