Targeting DNA repair pathways for cancer treatment: what's new?
Ontology highlight
ABSTRACT:
SUBMITTER: Kelley MR
PROVIDER: S-EPMC4125008 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Targeting DNA repair pathways for cancer treatment: what's new?
Kelley Mark R MR Logsdon Derek D Fishel Melissa L ML
Future oncology (London, England) 20140501 7
Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A growing body of evidence indicates that tumors accumulate progressively more mutations in DNA repair proteins as cancers progress. DNA repair mechanisms greatly affect the response to cytotoxic treatments, so understanding those mechanisms and finding ways to turn dysregulated repair processes against themselves to induce tumor death is the goal of all DNA repair inhibition efforts. Inhibition may be direct or indi ...[more]
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