Retinoic acid activates two pathways required for meiosis in mice.
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ABSTRACT:
SUBMITTER: Koubova J
PROVIDER: S-EPMC4125102 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Retinoic acid activates two pathways required for meiosis in mice.
Koubova Jana J Hu Yueh-Chiang YC Bhattacharyya Tanmoy T Soh Y Q Shirleen YQ Gill Mark E ME Goodheart Mary L ML Hogarth Cathryn A CA Griswold Michael D MD Page David C DC
PLoS genetics 20140807 8
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Stra8, which is required for meiotic DNA replication and the subsequent processes of meiotic prophase. Here we report that RA also activates transcription of Rec8, which encodes a component of the cohesin complex that accumulates during meiotic S phase, and which is essential for chromosome syna ...[more]
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