Ontology highlight
ABSTRACT:
SUBMITTER: Garcia SM
PROVIDER: S-EPMC4125460 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Garcia Susana M D A SM Tabach Yuval Y Lourenço Guinevere F GF Armakola Maria M Ruvkun Gary G
Nature structural & molecular biology 20140720 8
Myotonic dystrophy disorders are caused by expanded CUG repeats in noncoding regions. Here we used Caenorhabditis elegans expressing CUG repeats to identify genes that modulate the toxicity of such repeats. We identified 15 conserved genes that function as suppressors or enhancers of CUG repeat-induced toxicity and that modulate formation of nuclear foci by CUG-repeat RNA. These genes regulate CUG repeat-induced toxicity through distinct mechanisms including RNA export and clearance, thus sugges ...[more]