Ontology highlight
ABSTRACT:
SUBMITTER: Nance E
PROVIDER: S-EPMC4125545 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nance Elizabeth E Timbie Kelsie K Miller G Wilson GW Song Ji J Louttit Cameron C Klibanov Alexander L AL Shih Ting-Yu TY Swaminathan Ganesh G Tamargo Rafael J RJ Woodworth Graeme F GF Hanes Justin J Price Richard J RJ
Journal of controlled release : official journal of the Controlled Release Society 20140628
The blood-brain barrier (BBB) presents a significant obstacle for the treatment of many central nervous system (CNS) disorders, including invasive brain tumors, Alzheimer's, Parkinson's and stroke. Therapeutics must be capable of bypassing the BBB and also penetrate the brain parenchyma to achieve a desired effect within the brain. In this study, we test the unique combination of a non-invasive approach to BBB permeabilization with a therapeutically relevant polymeric nanoparticle platform capab ...[more]