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Gene-gene interactions in breast cancer susceptibility.

ABSTRACT: There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 × 10(-4); ATM and BRCA1, P= 0.01; ATM and BRCA2, P= 0.02; CHEK2 and BRCA1/BRCA2 combined, P = 2.1 × 10(-4); CHEK2 and BRCA1, P= 0.01; CHEK2 and BRCA2, P= 0.01). The interactions are such that the resultant risk of breast cancer is lower than the multiplicative product of the constituent risks, and plausibly reflect the functional relationships of the encoded proteins in DNA repair. These findings have important implications for models of disease predisposition and clinical translation.

SUBMITTER: Turnbull C 

PROVIDER: S-EPMC4125627 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Gene-gene interactions in breast cancer susceptibility.

Turnbull Clare C   Seal Sheila S   Renwick Anthony A   Warren-Perry Margaret M   Hughes Deborah D   Elliott Anna A   Pernet David D   Peock Susan S   Adlard Julian W JW   Barwell Julian J   Berg Jonathan J   Brady Angela F AF   Brewer Carole C   Brice Glen G   Chapman Cyril C   Cook Jackie J   Davidson Rosemarie R   Donaldson Alan A   Douglas Fiona F   Greenhalgh Lynn L   Henderson Alex A   Izatt Louise L   Kumar Ajith A   Lalloo Fiona F   Miedzybrodzka Zosia Z   Morrison Patrick J PJ   Paterson Joan J   Porteous Mary M   Rogers Mark T MT   Shanley Susan S   Walker Lisa L   Ahmed Munaza M   Eccles Diana D   Evans D Gareth DG   Donnelly Peter P   Easton Douglas F DF   Stratton Michael R MR   Rahman Nazneen N  

Human molecular genetics 20111109 4

There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 × 10(-4); ATM and BRCA1, P= 0.01; ATM and BRCA2, P= 0.02; CHEK2 and BRCA1/BRCA2 combined, P = 2.1 × 10(-4); CHEK2 and BRCA1, P= 0.  ...[more]