Role of lipotoxicity in endothelial dysfunction.
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ABSTRACT:
SUBMITTER: Kim JA
PROVIDER: S-EPMC4126197 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Role of lipotoxicity in endothelial dysfunction.
Kim Jeong-a JA Montagnani Monica M Chandrasekran Sruti S Quon Michael J MJ Quon Michael J MJ
Heart failure clinics 20120810 4
Vascular endothelial dysfunction is determined by both genetic and environmental factors that cause decreased bioavailability of the vasodilator nitric oxide. This is a hallmark of atherosclerosis, hypertension, and coronary heart disease, which are major complications of metabolic disorders, including diabetes and obesity. Several therapeutic interventions, including changes in lifestyle as well as pharmacologic treatments, are useful for improving endothelial dysfunction in the face of lipotox ...[more]
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