Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.

ABSTRACT:

Objective

The rs10757278, rs1333049 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus associated with a prevalence of acute coronary syndromes (ACS). Reports concerning their association with long-term outcome after an ACS are equivocal. The aim of our study was to investigate the association of the 9p21.3 locus with 5-year overall mortality in patients with ST-elevation myocardial infarction (STEMI).

Materials and methods

We performed a retrospective analysis of data collected prospectively in 2 independent registries of consecutive patients with STEMI (derivation and validation group). Genotyping was performed with the TaqMan method. The analyzed end-point was total mortality.

Results

The derivation group comprised 589 patients: 25.3%

SUBMITTER: Szpakowicz A 

PROVIDER: S-EPMC4126747 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature